Rajeev Sharma, Udita Agrawal and Suresh P. Vyas Pages 21 - 34 ( 14 )
The oral delivery of therapeutics is of paramount importance to medical application and advancement. There has been remarkable advancement in the field of polymeric formulations for oral delivery of therapeutics. Novel polymeric formulation like polymeric nanoparticles, micelles and dendrimers are exploited and researched to further improve the bioavailability, stability, permeability and therapeutic efficacy. Over the last years, there have been number of approaches used for the effective delivery of bioactive(s). These include chemical modification, use of enzyme inhibitors and permeation enhancers, and novel drug delivery systems. Numerous polymeric nanoarchitectures based strategies are able to overcome restrictions and show the promising approach for efficient [P/P] drugs oral delivery. The aim of present review focuses on the need for the development of polymeric nanocarrier for oral-peptide and protein delivery with emphases on insulin delivery via various polymeric nanocarriers.
Caco-2 cell monolayers, dendrimers, nanoparticles, oral delivery.
Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Dr. H. S. Gour Viswavidyalaya, Sagar-470003 M.P, India.