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Anticancer Drug Sensitivity Testing, a Historical Review and Future Perspectives

[ Vol. 10 , Issue. 1 ]

Author(s):

Da-Yong Lu*, Ting-Ren Lu, Jian Ding, Bin Xu, Jin-Yu Che and Hong-Ying Wu   Pages 44 - 55 ( 12 )

Abstract:


Background: Clinical cancer treatment and therapy have been gradually improved by experimental and clinical advancements worldwide, especially after the advent of different types of individualized cancer therapy (ICT).

Objective: Despite the longest history of anticancer drug sensitivity testing (DST) among ICT, its therapeutic applications for clinical cancer trials need to be updated.

Methods: DST techniques are widely diversified and improved a great deal, but they have not been matured to cure all cancer patients in clinics.

Results: The retrospection and panorama of historic and evolutionary developments of DST including clinical relevance, advantageous, technical cautions, limitations of varied models and methodologies at present stage are addressed.

Conclusion: Future directions and novel ideas must be established.

Keywords:

Anticancer drugs, cancer stem cell, clinical cancer therapy, drug combinations, drug sensitivity test, individualized cancer therapy, neoplasm metastasis.

Affiliation:

School of Life Sciences, Shanghai University, Shanghai 200444, P.R. China.

Graphical Abstract:



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