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Analysis of Safety Outcomes in Chronic Hepatitis C Patients using Interferon-free Treatment: A Systematic Review of Case Reports

[ Vol. 14 , Issue. 3 ]

Author(s):

Vinicius Lins Ferreira*, Leticia Paula Leonart, Ana Maria Della Rocca and Roberto Pontarolo   Pages 210 - 219 ( 10 )

Abstract:


Background: Second generation direct acting-antivirals are safe and effective treatments for chronic hepatitis C patients.

Objective: We aimed to conduct a systematic review of case reports and case series to evaluate the safety of the drugs, highlighting a compilation of AE not previously reported in other reviews.

Methods: The search was performed in four electronic databases and included only case reports and case series that evaluated interferon-free therapies and provided safety outcomes.

Results: Initially 1,235 records were retrieved, and after screening 30 studies were included in the analysis (23 case reports and 7 case series). A total of 39 patients were included, receiving eight different interferon-free treatments. Nineteen patients discontinued treatment (only 8 of these achieved treatment response). Other 19 patients achieved SVR without discontinuation. Rare adverse events were observed, including breast hypertrophy, retinopathy and drug-induced infection. Some patients were in an advanced stage of the disease, and were therefore unable to withstand treatment due to the appearance of complications.

Conclusion: In this sense, it is important to monitor the use of these drugs that can favor the appearance of serious AE. (PROSPERO registration number CRD42016051680).

Keywords:

Interferon-free, hepatitis C, case report, systematic review, case series, treatment.

Affiliation:

Pharmaceutical Sciences Post-Graduate Program, Universidade Federal do Paraná, Curitiba, Pharmaceutical Sciences Post-Graduate Program, Universidade Federal do Paraná, Curitiba, Pharmaceutical Sciences Post-Graduate Program, Universidade Federal do Paraná, Curitiba, Pharmaceutical Sciences Post-Graduate Program, Universidade Federal do Paraná, Curitiba

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