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CORONAVIRUS and COVID-19: A Systematic Review and Perspective

[ Vol. 15 , Issue. 5 ]

Author(s):

Harshal Ashok Pawar*, Anjali Harshal Pawar, Sandip Ashok Pawar and Prashant Ashok Pawar   Pages 423 - 435 ( 13 )

Abstract:


Coronavirus (CoV) is an enveloped positive-sense RNA virus. Coronavirus disease 2019 (COVID-19) is an acute respiratory disease, induced by a new type of coronavirus, SARS-CoV-2. COVID-19 has originated in China and spread quickly all over the world. WHO acknowledged the outbreak of a global pandemic on March 11, 2020. The spread of COVID-19 signified a big threat to social life, the economy, and public health. As of April 14, 2020, WHO reported a total of 1,812,734 confirmed cases of COVID-19 and 113,675 (6.27 %) deaths throughout the world. Numerous nations around the globe took assorted measures because of the danger of SARS-CoV-2 and created wide-ranging preventive approaches. No particular drug or vaccines/antibodies are yet accessible for the treatment of this unforeseen and lethal illness. The pandemic has brought about travel limitations and across the country lockdowns in most of the nations. The objective behind this article was to provide recent updates and well-authenticated information to the scientific community, health care personnel’s and common public about Coronavirus, their types, characteristic features, structure and origin, mode of transmission, pathogenesis, clinical symptoms, diagnostic methods, drug development approach, prevention and treatment of COVID-19.

Keywords:

COVID-19, SARS-CoV-2, MERS-CoV, coronavirus, antiviral drugs, RNA.

Affiliation:

Department of Pharmacognosy, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar-421003, Maharashtra, Naturopathiest, Aai Nature Cure, Ram Baug Lane-1, Kalyan (W)-421301, Maharashtra, Manufacturing Science and Technology, Sandoz - A Division of Novartis, Kalwe, Navi Mumbai-400708, Maharashtra, Executive-External Manufacturing, Glenmark Pharmaceuticals Pvt. Ltd., Andheri (E), Mumbai-400099, Maharashtra

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