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Hybrid Liquisolid Technique: A Novel Approach to Enhance the In-vitro Performance of Antidiabetic Drugs


Saloni Dalwadi *, Vaishali T. Thakkar and Hardik B. Rana   Pages 1 - 14 ( 14 )


Background: A combination of Glimepiride and Boswellia serrata extract reduces neuropathic diabetic complications by reducing the peroxidase level and improving the antioxidant level. The hybrid liquisolid method includes a combination of two methods, kneading and the liquisolid method, to enhance the drug’s in-vitro performance.

Objective: The objective of this study was to enhance the in-vitro performance of antidiabetics drugs.

Methods: Tablets involving a fixed-dose combination of Glimepiride and Boswellia serrata extract were formulated by kneading method followed by liquisolid method. Screening of non-volatile solvents, carriers, and coating materials was carried out. The experiment was designed to optimize the formulation and the obtained model was validated concerning the design of the experiment. 3 level 2 factorial (32) design was applied by using Design expert software 11. Various pre-compression parameters were assessed to check the quality of the formulation.

Results: Screening of excipients for kneading method, including Glimepiride with PVP K 30 (5%), and Boswellia serrata extract with Poloxamer 188 (13%), provided optimum drug release. For the liquisolid method, propylene glycol:PEG 400: Tween 80 (1:2:4) ratio for Glimepiride and PEG 400: Tween 80 (1:3) ratio for Boswellia serrata extract were selected. Common carrier and coating material for both drugs were selected to improve the in-vitro performance of the drug.

Conclusion: This study enables an overall understanding of the impact of excipients on the quality of formulation, which may provide critical knowledge for the implementation of liquisolid systems.


Hybrid liquisolid technique, kneading method, 32 factorial design, Glimepiride, Boswellia serrata extract.


Department of Pharmaceutics Anand Pharmacy College, Anand, Gujarat, Anand Pharmacy College, Anand, Gujarat, Department of Pharmaceutics, Anand Pharmacy College

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