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Hybrid Liquisolid Technique: A Novel Approach to Enhance the In-vitro Performance of Antidiabetic Drugs

Author(s):

Saloni Dalwadi *, Vaishali T. Thakkar and Hardik B. Rana   Pages 1 - 14 ( 14 )

Abstract:


Background: A combination of Glimepiride and Boswellia serrata extract reduces neuropathic diabetic complications by reducing the peroxidase level and improving the antioxidant level. The hybrid liquisolid method includes a combination of two methods, kneading and the liquisolid method, to enhance the drug’s in-vitro performance.

Objective: The objective of this study was to enhance the in-vitro performance of antidiabetics drugs.

Methods: Tablets involving a fixed-dose combination of Glimepiride and Boswellia serrata extract were formulated by kneading method followed by liquisolid method. Screening of non-volatile solvents, carriers, and coating materials was carried out. The experiment was designed to optimize the formulation and the obtained model was validated concerning the design of the experiment. 3 level 2 factorial (32) design was applied by using Design expert software 11. Various pre-compression parameters were assessed to check the quality of the formulation.

Results: Screening of excipients for kneading method, including Glimepiride with PVP K 30 (5%), and Boswellia serrata extract with Poloxamer 188 (13%), provided optimum drug release. For the liquisolid method, propylene glycol:PEG 400: Tween 80 (1:2:4) ratio for Glimepiride and PEG 400: Tween 80 (1:3) ratio for Boswellia serrata extract were selected. Common carrier and coating material for both drugs were selected to improve the in-vitro performance of the drug.

Conclusion: This study enables an overall understanding of the impact of excipients on the quality of formulation, which may provide critical knowledge for the implementation of liquisolid systems.

Keywords:

Hybrid liquisolid technique, kneading method, 32 factorial design, Glimepiride, Boswellia serrata extract.

Affiliation:

Department of Pharmaceutics Anand Pharmacy College, Anand, Gujarat, Anand Pharmacy College, Anand, Gujarat, Department of Pharmaceutics, Anand Pharmacy College



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